Thin Prep LBC PAPA TEST and HPV testing- from now on can be done in our Polyclinic too.

Fluid cytology LBC (liquid-based cytology) is the first significant improvement of PAPA test since it was introduced during the 1950s.

Because of numerous advantages, ThinPrep PAPA test represents a more reliable and accurate method of detecting atypical cells of cervical cancer and changes that precede it (cancerous- LSIL-CIN1 and HSIL-CIN2/CIN3)

While traditional PAPA test on the glass implies cytological analysis of a multilayer preparation on the glass slide, ThinPrep PAPA test is based on method of liquid cytology (LBC). The way of taking a sample is the same like with usual PAPA test, but the sample is placed in a small container with liquid that preserves the sample. Such prepared a single cell layer preparation is easier for further processing.

Compared to the conventional PAPA test, ThinPrep PAPA test advantages are:

  • Diagnostic accuracy increased for 60% and reduced number of imprecise diagnosis which unnecessary concern the patients (ASCUS) – applying layer of cells on the glass slide is automatized and preparation first goes through the computer evaluation and only after that cytologist examines it
  • All the collected cells go to the analysis whereas with classic PAPA test only a part of collected cells is smeared over the glass slide
  • Every cytological sample is stored in a separate bottle with saline and when it arrives into the cytological laboratory, the sample is mixed with other samples in the colouring pools, and the cells are applied to glass slide with a special device in the laboratory.
  • 50%-90% less samples which are considered unsatisfactory (contaminated with traces of blood, mucus or inflammatory cells) compared to classic PAPA test
  • According to all researches, ThinPrep PAPA is a sensitive method for diagnosing glandular abnormal changes, especially adenocarcinoma, which is very important because such changes are sometimes missed if the conventional PAPA test is done
  • Every sample is being kept up to 6 months, which enables some additional subsequent examinations without the need for repeated taking of patient’s sample *Additional molecular testing (HPV typing, HPV mRNA, chlamydia, myco plasma, ureaplasma, trichomonas, herpes simplex…) By immunocytochemical tests (L1, p16/Ki67)
dodatnim molekularnim pretragama (HPV tipizacija, HPV mRNA, chlamydia, mycoplasma, ureaplasma, trichomonas, herpes simplex...)

imunocitokemijskim testovima (L1, p16/Ki67)

If you have changes on PAPA test, that your gynaecologist or cytologist aren’t sure whether they belong to abnormalities related to HPV, feel free to contact our Polyclinic regarding additional processing by LBC PAPA test (in co-operation with Synlab Zagreb)

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